RiteMED Paracetamol Mechanism of Action

120 mg/5 mL Syrup: Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentration occurring about 30 minutes to 2 hours after ingestion. It is metabolized in the liver and excreted in the urine mainly as glucuronide and sulphate metabolites of paracetamol were reduced after administration of salicylamide. The elimination half-life varies from about 1 to 4 hours. Plasma protein binding is negligible at usual therapeutic concentration but increases with increasing concentrations.
250 mg/5 mL Syrup: Paracetamol is readily absorbed from the gastrointestinal tract with peak plasma concentration occurring about 10 minutes to 60 minutes after oral administration. It is metabolized in the liver and excreted in the urine mainly as glucuronide and sulphate conjugates. Less than 5% is excreted as unchanged paracetamol. The elimination half-life varies from about 1 to 3 hours. Plasma protein binding is negligible at unusual therapeutic concentration but increases with increasing concentrations.